In our patient we performed a broad multidirectional differential diagnostic tests evaluating the immune response, allergy, autoimmunization and infections, showing positive Epstein-Barr virus (EBV)-DNA and abnormalities in adaptive immune response such as increased values of CD8+ T lymph cells and decreased values of CD4+ T lymph cells accompanied by features of defective B lymph cell maturation, with decreased formation in the switched and non-switched memory cells. This evidence concerns the gene CD8A and infection.