MBTPS1 and Sepsis: Preservation of cardiac function in sepsis by FTY720 is at least in part secondary to the activation (by S1P) of the S1P2 (and possibly S1P3) resulting in the PI3K-dependent activation of the Akt/eNOS and ERK1/2 pathways, which are known to be cardioprotective in animal models of sepsis.