Additionally, CTNNB1 mutations have been found as an early alteration in a subset of hepatocellular adenomas transformed to HCC, while TERT promoter mutations were associated with late stages of adenoma to carcinoma transition suggesting an interplay between telomerase maintenance and Wnt/β-catenin pathway in last step of malignant transformation [42, 55]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.