This region harbors two crucial tumors suppressors - DCC (deleted in colorectal cancer) and SMAD4. SMADs are key intracellular components of TGF-β/BMP pathway, one of the most frequently inactivated ones in colorectal carcinomas (30-40% tumors) [3, 54]. The gene discussed is TGFB1; the disease is colorectal carcinoma.