Finally, in 2013 Enric Domingo et al analyzed somatic mutations in 906 specimens (stages II and III) taken from patients participating VICTOR clinical trial and found many associations, both novel and well-known (e.g. co-incidence of CIN and mutations of TP53; MSI and BRAF mutation). This evidence concerns the gene TP53 and cervical squamous intraepithelial neoplasia.