APC and cervical squamous intraepithelial neoplasia: Losses or truncations of APC cause mitotic spindle defects that, upon somatic inactivation of other CIN-associated genes (e.g. spindle and cell cycle checkpoint genes, DNA repair, telomere maintenance, etc.)results in chromosomal abnormalities and aneuploidy as observed in the most of CIN-positive CRCs [17].