Markers of unfavorable prognosis: CIN; deletions in 18q (discussable), 8p, 4p, 15q regions and inactivation of SMAD4, DCC, lengthening of telomeres in CIN tumors; CIMP-H in combination with MSS; BRAF mutations in MSS or MSI-L tumors; mutations in PIK3CA (20th exon), KRAS, NRAS. This evidence concerns the gene SMAD4 and cervical squamous intraepithelial neoplasia.