AVPR1B and major depressive disorder: We also identified another three smoking-related genomic regions with more than two AA-related sites that were associated with aging-related diseases: AVPR1B (Arginine Vasopressin Receptor 1B) contributes to overweight and might related with diabetes development [27], CNTNAP2 (Contactin Associated Protein-Like 2) is demonstrated to be associated with several mental diseases (e.g. autism, schizophrenia, epilepsy and depression) [28–30], and KCNQ1 (Voltage Gated KQT-Like Subfamily Q, Member 1) is another well-known gene for type 2 diabetes [31].