Genes implicated in BCR (IgHV, IgKV) and T-Cell Receptor (TCR) assembly (TRAJ and TRAV) and transcriptional regulation, such as NFE2l2, MTERF4, HES1, EXOSC8, NARFL and ZNF414, were affected by either duplication or deletion in at least 20% of LR DLBCL samples. This evidence concerns the gene BCR and diffuse large B-cell lymphoma.