Cell cycle regulation and apoptosis were the most represented of affected pathways, with a high number of alterations encompassing CDKN2A/B, PRDM1, BCL2, TP53 and XPO1. Deletions of CDKN2A/B and IBTK were identified in 28% and 23% of DLBCL samples, respectively. This evidence concerns the gene IBTK and diffuse large B-cell lymphoma.