AUC value of betatrophin in PDAC-DM patients (0.853) was higher than PDAC-IGT (0.668) and PDAC-NGT (0.694), while AUC value of CA19-9 in PDAC-DM patients (0.792) was higher than PDAC-IGT (0.530) and PDAC-NGT (0.479). The gene discussed is ANGPTL8; the disease is diabetes mellitus.