Interestingly, although betatrophin was not correlated with fasting blood glucose (FBG) in all subjects, it was significantly associated with PDAC patients with various stages of glucose tolerance (PDAC-NGT [r= −0.589; P=0.015]; PDAC-IGT [r= −0.554; P=0.017]; PDAC-DM [r=−0.586; P=0.002], respectively). Here, ANGPTL8 is linked to diabetes mellitus.