Polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) are the irreplaceable glycosyltransferases that initiate and catalyze the synthesis of Carbohydrate antigens (CAs) [6, 7], which include some commonly used serum tumor markers, such as CA125 and CA19-9, for the evaluation of tumor burden, disease progression in various cancers including lung adenocarcinoma [6, 8–12]. Here, B4GALNT1 is linked to cancer.