Ascites was observed in 19.0% of 93 patients with HCC; portal hypertension, in 39.7% of 86 patients, hypoalbuminemia (<3 g/dL), in 8.6% of 93 patients; and a prothrombin time below 70%, in 21.0% of 83 patients. Here, F2 is linked to hepatocellular carcinoma.