Yan et al. [19] showed that our DLI protocol didn’t increase DLI-associated severe GVHD and kept the benefit of GVL effects, and (2) other immune cells, such as CD4+ helper T-cell counts and natural killer cells, may be effective cells in eradicating leukemia cells in spite of low counts after transplantation [31, 32]. This evidence concerns the gene CD4 and graft versus host disease.