The XLOC002437 lncRNA and COL6A6 are significantly downregulated at stage 1 of secondary HF, suggesting that the interaction of COL6A6 and XLOC002437 may regulate and reduce the collagen VI α6 chain deposition in the skin by positive feedback, thereby inhibiting skin fibrosis and promoting the formation and deposition of the placode. Here, COL6A6 is linked to hydrops fetalis.