In particular, the analyses were performed on HepG2 cell line with no viral infection but carrying wild-type p53 and with a CK8/18 expression similar to that of normal hepatocytes [30], and on the PLC/PRF/5 cell line, containing several copies of HBV DNA integrated in its genome [31] and carrying a mutated p53 gene (mutant p53 R249S) [32]. The gene discussed is KRT8; the disease is viral infectious disease.