Although the change in the BMD levels during the follow-up period was not statistically significant (Table 5, Fig 2A), the number of patients with the reduced BMD level, which was less than the cutoff value for osteoporosis, was increased from 13 patients (76%) in 1999 to 15 patients (88%) in 2011.17 During the follow-up period, the osteocalcin levels had decreased (Fig 2A), but the number of patients with osteocalcin levels greater than the cutoff value for osteoporosis was still high (16 patients [94%] in 1999; 15 patients [88%] in 2011). This evidence concerns the gene BGLAP and osteoporosis.