Based on the finding of Aleksic et al. that histone H3 (H3) co-precipitates with nIGF-1R in DU145 prostate cancer cell lines [23], we made mass spectrometry on immunoprecipitated IGF-1R from nuclear extracts of human cervical carcinoma cells (HeLa). The gene discussed is IGF1R; the disease is Familial prostate cancer.