YWHAH has been extensively screened in large cohorts of patients (>2000 cases) and controls (>1200 cases) because the YWHAH chromosomal location at 22q12.3 co-localizes with the susceptibility loci identified in schizophrenia,29,30,31,32 bipolar disorders33 and Parkinson disease.34 However, non-synonymous variants were never identified. Here, YWHAH is linked to Parkinson disease.