Although our results disagree with Hussein et al. [13] and Chavey et al. [18] who reported higher levels of IL-12 in BC patients than control subjects, this conflict may be attributed to the hormone receptor (ER, PgR and HER2) status, since similar to their findings, we recorded higher levels in ER, PgR and HER2 negative rather than positive patients which was statistically significant in PgR. The gene discussed is ESR1; the disease is breast cancer.