A recent meta-analysis on association between adiponectin concentration and diabetic retinopathy found a significant association and revealed high heterogeneity may be because of the plasma adiponectin levels are influenced by various factors such as; degree of obesity, age, blood lipid, gender, glucose level, kidney function, pharmacological therapy with thiazolidinediones [36]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.