Furthermore, Hadjadj et al., [27] reported that elevated adiponectin observed in diabetics with microvascular and macrovascular diseases; nephropathy, retinopathy, neuropathy and in a single patient with cardiomyopathy; that revealed an altered regulation of this adipocytokine in patients with complications associated with type 1 diabetes. The gene discussed is ADIPOQ; the disease is type 1 diabetes mellitus.