The diagnosis of HFpEF is based on existence of symptoms and signs for heart failure, normal or approximately normal ejection fraction (EF > 45-50%) and diagnosing of LV diastolic dysfunction by means of heart catheterization or Doppler echocardiography and/or elevated natriuretic peptide (BNP > 200 pg/ml) concentration As supplement were added the known criteria of the New York Heart Association (NYHA), which was more functional classification. This evidence concerns the gene NPPB and heart failure.