Cao [33] reported that the decreased bone mass with obesity may be due to increased marrow adipogenesis at the expense of osteoblastogenesis and / or increased osteoclastogenesis because of up regulated production of pro inflammatory cytokines and/or reduced adiponectin production and / or reduced calcium absorption associated with high fat intake. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.