The result of the current study showed that; not only the adiponectin serum level was low in patients with NAFLD, but also its level decreased more in the presence of NASH rather than simple steatosis, and even more the Adipo R gene expression in livers of patients with NASH showed a lower level than patients with simple steatosis. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatohepatitis.