Therefore, the focus of our interest was to evaluate predictors of obesity complications and the effect of childhood obesity on pro-inflammatory cytokines production as TGF-β1, IL-6, and haptoglobin, and to explore the relation between circulating levels of these cytokines and anthropometric measures among prepubertal overweight and obese Egyptian children. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.