On the contrary, other studies in obese adults showed decreased levels of TGF-β1 as in a study by Kinik et al., [39] who determined that obese children had lower TGF-β1 levels compared to leans, however, in a study by Kanra et al. [40] who reported the lack that the lack of an association between TGF-β1 polymorphisms and obesity in Turkish children. This evidence concerns the gene TGFB1 and obesity due to melanocortin 4 receptor deficiency.