Whereas males, being much more overweight than females, resulted with higher median level of total IgE in all disease groups, compared to controls and compared to female patients, particularly in urticaria/eczema male patients we found the highest median level of total IgE (350 IU/ml range 161-350) but not in rhinitis group were it was the lowest one (83.9 IU/ml range 4.39-350) (Table 4). This evidence concerns the gene IGHE and rhinitis.