However, we demonstrated that acute hypoxic exposure increases two-compartment models of insulin sensitivity (SI2∗) in human type 2 diabetics [23] with Lecoultre et al. [24] showing that ten nights of moderate hypoxic exposure improved insulin sensitivity in obese males, as measured by the 2-step hyperinsulinemic-euglycemic clamp method. The gene discussed is INS; the disease is type 2 diabetes mellitus.