In this study, it was found that the rs6721961 (−617C/A) polymorphism of Nrf2 gene was associated with diabetes in Mexican mestizo men, while the rs7211 polymorphism of TXNIP gene and the rs2071749 polymorphism of HMOX1 gene were associated with obesity. The gene discussed is NFE2L2; the disease is obesity due to melanocortin 4 receptor deficiency.