There was a significant interaction between FTO SNP rs8050136 and carbohydrate intake % energy) (Pinteraction = 0.04) on obesity, where the ‘A’ allele carriers of the SNP rs8050136 had 2.46 times increased risk of obesity than those with ‘CC’ genotype (P = 1.0 × 10−5) among individuals in the highest tertile of carbohydrate intake (% energy, 71 %) (Fig. 1). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.