FTO and obesity due to melanocortin 4 receptor deficiency: Previous study in the South Indian population (CURES) has shown that the FTO SNPs (rs1588413 and rs8050136) increased obesity risk by 1.27 and 2.06 times, which is equivalent to BMI increase by 0.33 and 0.54 kg/m2 per effect allele, respectively [7].