In addition, a recent investigation suggested that Shuizhi could inhibit tumor angiogenesis via improving tumor hypoxia microenvironment, which was partly attributed to decreasing the expression of mRNA and protein level of hypoxia inducible factor-1α (HIF-1α), and degrade the mRNA expression of vascular endothelial growth factor (VEGF), downstream gene of HIF-1α [95, 96]. The gene discussed is HIF1A; the disease is neoplasm.