More recently, Bougaki et al. examined the impact of NOS3 deficiency on systemic inflammation and myocardial dysfunction in vivo and in cardiomyocytes isolated from mice subjected to peritonitis-induced polymicrobial sepsis and reported that NOS3 protects against systemic inflammation and myocardial dysfunction during polymicrobial sepsis [119]. This evidence concerns the gene NOS3 and Sepsis.