In particular, Peng et al. [42] demonstrated that the subunit gp91phox of NADPH oxidase plays a critical role in myocardial depression induced by endotoxemia and that gp91phox-containing NADPH oxidase signaling contributes to LPS-stimulated TNF-α expression in cardiomyocytes. The gene discussed is FMO5; the disease is serum lipopolysaccharide activity.