IL1B and periodontitis: A cross-sectional study in adults (20–89 years) reported that IL-1β levels were significantly higher in participants with periodontitis (144 pg/mL) compared to healthy participants (61 pg/mL), but there was no difference in salivary IL-1β concentrations between smokers (52 pg/mL) and non-smokers (78 pg/mL) [30].