We tested the association of RA susceptibility HLA–DRB1 amino acids with the C‐reactive protein (CRP) level, the tender joint count (TJC), the swollen joint count (SJC), the Disease Activity Score in 28 joints (DAS28), and the Health Assessment Questionnaire (HAQ) score in the Norfolk Arthritis Register (NOAR) and Early Rheumatoid Arthritis Study (ERAS) cohorts. This evidence concerns the gene CRP and rheumatoid arthritis.