Therefore, to identify the relative contribution of adipocyte PIKfyve to the observed dysregulation of glucose homeostasis as well as to begin exploring the potential mechanisms for the systemic glucose intolerance and insulin resistance, we have generated another fat‐tissue specific Pikfyve KO (knockout) model, in which expression of Cre recombinase is driven by the promoter of adiponectin, a gene that is strictly adipose‐specific (Wang et al. Here, PIKFYVE is linked to Insulin resistance.