Through the evaluation of cardiovascular parameters and hypothalamic gene expression in conscious, freely moving mice our main findings are as follows: (1) HFD and HFHSu induced obesity in mice, but only HF diet regimen was associated with hypertension; (2) HFD displayed two hemodynamic phenotypes in mice namely hypertension and resistant to hypertension; (3) Hypertensive HFD‐fed mice exhibit autonomic imbalance and increased CART mRNA levels in hypothalamus, but not in brainstem and CART‐positive neurones at the DMH. The gene discussed is CARTPT; the disease is obesity due to melanocortin 4 receptor deficiency.