Through the evaluation of cardiovascular parameters and hypothalamic gene expression in conscious, freely moving mice our main findings are as follows: (1) HFD and HFHSu induced obesity in mice, but only HF diet regimen was associated with hypertension; (2) HFD displayed two hemodynamic phenotypes in mice namely hypertension and resistant to hypertension; (3) Hypertensive HFD‐fed mice exhibit autonomic imbalance and increased CART mRNA levels in hypothalamus, but not in brainstem and CART‐positive neurones at the DMH. This evidence concerns the gene CARTPT and hydrops fetalis.