In recent decades, research on membrane-bound B7-H3 (mB7-H3), has revealed an abnormally high expression of mB7-H3 in a wide variety of human tumor tissues, which is closely correlated with an unfavorable progression and a poor prognosis for cancer patients, implying that the mB7-H3 expression level can be used as a tumor biomarker7, 8. Here, CD276 is linked to neoplasm.