According to our research, the expression of IL-8 and VEGF was up-regulated through the TLR4/NF-κB pathway in the presence of sB7-H3 in PCa cells, which suggests that sB7-H3 facilitates the formation of nascent blood vessels by increasing the expression of IL-8 and VEGF. Here, CXCL8 is linked to posterior cortical atrophy.