However, although the mechanism by which B7-H3 affects tumor progression is not clear, some studies have discovered B7-H3-mediated mechanisms of resistance to anti-cancer drugs, such as paclitaxel and gemcitabine, that act partly through the Jak2/Stat3 pathway and involve increased levels of Mcl-1 and survivin proteins9, 10. This evidence concerns the gene STAT3 and cancer.