MAP1LC3A and infection: The binding impairment displayed by the A300 allele correlated with reduced LC3 lipidation in response to S. aureus infection (Fig. 7a), decreased labelling of bacterial phagosomes with LC3 (Fig. 7b) and increased recovery of colony-forming units from infected cells (Fig. 7c), indicating that the T300A mutation causes defective xenophagy and reduced control of the infection at an early stage.