Nevertheless, myelin and axon area increased by 1.35 and 1.43 fold (mean +/- SEM: 8.417+/-0.1819 and 6.459+/-0.2425, p<0.001 in both) and 1.39 and 1.47 fold (mean +/- SEM: 8.658+/-0.2163 and 6.603+/-0.1979, p<0.001 in both) in the IGF-1 and CH groups versus controls (mean +/- SEM: 6.248+/-0.1495 and 4.506+/-0.1471), respectively. Here, IGF1 is linked to cyclic hematopoiesis.