Despite the substantial decrease in the expression across groups after surgery, the product of NF-M staining was 1.8 fold higher (mean +/- SEM: 7.511+/-0.6974, p = 0.002) in the CH group whereas in IGF-1 and IGF-1+CH nerve, the staining was 1.6- and 1.4 fold less (mean +/- SEM: 2.624+/-0.4533 and 2.925+/-0.2124) as compared to controls (mean +/- SEM: 4.165+/-0.6294), respectively. The gene discussed is NEFM; the disease is cyclic hematopoiesis.