KLK3 and adenocarcinoma: Saw palmetto extracts inhibited 5α-reductase and decreased growth of human prostatic cells in vitro [5–7], decreased prostate tumor progression and prostate DHT concentrations in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice [8], decreased prostate growth and hyperplasia in castrated, DHT-implanted, sulpiride-treated rats [9], inhibited testosterone-induced prostate growth [10] and hyperplasia [11] in rats, and decreased prostate specific antigen (PSA) levels in men with enlarged prostates [12].