In this study, we used mice that lack MHC Ia (Kb-/-Db-/-), MHC Ia/M3 (Kb-/-Db-/-M3-/-) [34] or β2m (β2m-/-) to study the role of M3-restricted and other MHC Ib-restricted CD8+ T cells in immunity against Mtb aerosol infection. Here, CD8A is linked to infection.