CACNA1C and Behcet disease: These studies differ in the rs1006737 alleles that were associated with mood disorders and their endophenotypes and so the impact of gender on genetic association at this locus remains unclear.37 It is possible that increased baseline DNA methylation of CGI 3 in females may provide a mechanism through which the risk allele of CACNA1C could determine sex-specific endophenotypes of BD.