CACNA1C and bipolar disorder: Interestingly, the mQTL SNPs identified in this study were in moderate LD with the bipolar GWAS top hit rs4765913 (index SNP) with r2=0.32 for rs2239030, r2=0.3 for rs2238056 and r2=0.4 for rs10848634 according to results from the PGC Bipolar Disorder Working Group.7 This finding supports the hypothesis that the well-established risk SNPs in CACNA1C for BD may have a role in DNA methylation status.