CYP2E1 and Cognitive impairment: Furthermore, using comb-p to identify DMRs for sociocognitive and intellectual impairments, we found that DNA methylation across the nine CpG sites in the deprivation-associated CYP2E1 DMR on chromosome 10 was significantly associated with ToM (combined P=4.87 × 10−9; Table 3 and Figure 3b) and cognitive impairment (combined P=2.912 × 10−5).