Consequently, a cross-over study in healthy subjects has shown that exposure to CML-levels of 5.4 mg CML/day (GC-MS analysis) for one month resulted in lower insulin sensitivity, lower plasma levels of omega-3 fatty acids, and higher concentrations of blood lipids than after a low-AGE diet (2.2 mg CML/day) [3]. Here, INS is linked to chronic myelogenous leukemia, BCR-ABL1 positive.