Macrophages in tumor tissues have their specific sources; tumor-derived chemokines and corresponding macrophage receptors play a critical role in the recruitment of monocytes/macrophages, such as C-C chemokine receptor type 2(CCR2)/ chemical chemokine 2 (CCL2), vascular endothelial growth factor receptor 1 VEGFR1/VEGF-A, L-selectin (CD62L)/CD62L ligands, and chemokine (C-X3-C motif) receptor 1 (CX3CR1)/ chemokine (C-X3-C motif) ligand 1 (CX3CL1). The gene discussed is CX3CL1; the disease is neoplasm.