In addition to reduced number of CD31 positive endothelial cells, inhibition on endothelial cell differentiation IL-24 can also modulate angiogenesis by suppressing growth factors, such as vascular endothelial growth factor (VEGF), IL-8, fibroblast growth factor (FGF) and transforming growth factor (TGF), produced by tumor cells [29]. This evidence concerns the gene VEGFA and neoplasm.