CHI3L1 and cancer: In addition, expression levels of cell cycle (CDK2, CDC2, CCND2) and inflammation markers linked to cancer (NOS2, TGFβ1, CHI3L1 and TFPI) were significantly increased in Caco-2WT/miR-373 compared with Caco-2WT/miR-c, but decreased in Caco-2D299G/α-miR-373 compared with Caco-2D299G/α-miR-c (Fig 5B).