GFAP and schizophrenia: This is in agreement with another study where GFAP-labeled cells had changed in morphology in the prefrontal cortex of schizophrenics, being more stained and stunted, whereas also having a 2.4-fold increase in protein concentration and 30% increase in mRNA expression.73 Other studies have also shown that GFAP mRNA expression changes in schizophrenia.