ADAMTS10 and glaucoma: However, in moderate glaucoma, these dogs develop clear changes in the laminar tissues with an interlaminar spacing decrease of roughly 60% (i.e., the spacing between the lamellae of the laminar cribrosa decreases from 25 μm to 10 μm) and reduced lamina cribrosa pore alignment and pore size that progresses to near obliteration of laminar pore spacing with severe glaucoma.[31] Similar changes are also seen in the experimental hypertensive dogs, indicating that these changes are secondary to IOP elevations and not a direct result of the ADAMTS10 mutation.[34]