ADAMTS10 and glaucoma: Extracellular matrix remodeling in response to chronic IOP elevations might further speed up the stiffening; while the effect of the ADAMTS10 mutation may act in the opposite direction, as the mutation impacts the extracellular matrix from an early age prior to glaucoma onset.[35] We hypothesized that age-associated stiffening in the affected dogs would be more pronounced than the normal dogs due to their simultaneous exposure to IOP elevations.