ADAMTS10 and isolated ectopia lentis: Clinical findings in ADAMTS10-mutant dogs prior to euthanasia were consistent with previously reported age- and disease-stage-related abnormalities;[18, 27, 28, 35, 49] these symptoms included slowly progressive rise of IOP with resulting optic nerve atrophy/cupping and associated vision loss, buphthalmia, ectopia lentis, secondary cataract formation and corneal edema.