Sensitivity was greater in participants with enrolment CD4<100 vs. CD4 ≥100x106/l: using grade 1 cut-off 17.1% (95% CI 6.6%, 33.6%) vs. 9.5% (95% CI 1.2%, 30.4%) for all TB, and 16.7% (95% CI 4.7%, 37.4%) vs. 6.3% (95% CI 0.2%, 30.2%) for confirmed TB. The gene discussed is CD4; the disease is tuberculosis.