WRN and Fanconi anemia: For example, VC treatment led to the reactivation of the DNA replication pathway that was repressed in WRN-deficient MSCs (Fig. 4B) (Zhang et al., 2015), and of the various DNA repair pathways including mismatch repair, homologous recombination, base excision repair, and Fanconi anemia pathway (Zhang et al., 2015) (Fig. 4B).