The multisite ATCG 5164 study published by Zolopa and colleagues in 2009 demonstrated a statistically favorable composite outcome (proportion of individuals alive, free of AIDS and with undetectable viral load) at 48 weeks after enrolment in patients presenting with an OI (including cryptococcal meningitis, but excluding TB) in whom HAART was initiated in the first 2 weeks in comparison to those who initiated between 6 to 12 weeks, especially in more immunosuppressed patients with CD4 counts less than 50 cells/mm3 [7]. Here, CD4 is linked to tuberculosis.