Disruption to this highly regulated process can lead to developmental and neurological disorders such as Beckwith-Wiedemann Syndrome (BWS), Angelman Syndrome (AS) and Prader-Willi Syndrome (PWS), which are characterized by genetic and epigenetic errors at the KCNQ1OT1 (BWS), H19 (BWS) and SNRPN (AS and PWS) imprinting control regions (ICRs) [16–22]. Here, SNRPN is linked to Prader-Willi syndrome.