Consistent with the results from microarray studies and qPCR validation, CoCl2-induced expression levels of EFEMP1 were significantly lower after HIF2α inhibitor 76 treatment in multiple breast cancer cell types (Figure 4D), suggesting that hypoxia-induced HIF2α expression is highly associated with enhanced EFEMP1 expression in breast cancer. The gene discussed is EPAS1; the disease is breast carcinoma.