Since SUM149PT and SUM1315MO2 cells have upregulated FASN and COX-2 pathways, we screened the effects of FASN inhibitor C75 and COX-2 inhibitor celecoxib or both in combination on the breast cancer cell lines using caspase 9 and caspase 3/7 assays. This evidence concerns the gene CASP9 and breast carcinoma.